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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis

Fig. 4

Effects of selective tropomyosin-receptor-kinase A (TrkA) inhibitor AR786 on pain behaviour and ankle swelling following collagen-induced arthritis (CIA). Rats were sensitised and challenged to type II bovine collagen in incomplete Freund’s adjuvant. Oral doses of 30 mg/kg AR786, twice daily or 35 mg/kg ibuprofen once daily were administered from the day of collagen challenge. a On day 17 pain was measured in the rats using a Randall Selito device. CIA was associated with decreased force required to elicit a withdrawal response. AR786 or ibuprofen each increased the force required to elicit a response to values that did not differ significantly from non-arthritic controls. b AR786 (diamonds) or ibuprofen (open squares) each resulted in significant inhibition of ankle swelling compared to vehicle-treated rats with CIA (triangles) (each p < 0.005), but the effect did not reach control levels (circles) (each p < 0.007) (AUC (mm/day) vehicle-treated non-arthritic control 22.6 (95 % CI 21.5 to 23.6), vehicle-treated CIA 33.4 (95 % CI, 31.9 to 34.8), AR786-treated CIA 28.0 (95 % CI 26.1 to 30.0), ibuprofen-treated CIA 27.0 (95 % CI, 26.0 to 28.1); analysis of variance F = 32.3, p < 0.001. *p < 0.05, **p < 0.01, ***p < 0.001 versus vehicle (5 % Gelucire) controls

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