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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: E2 regulates MMP-13 via targeting miR-140 in IL-1β-induced extracellular matrix degradation in human chondrocytes

Fig. 1

E2 induced miR-140 expression in time and concentration dependent. a Influence of E2 (10 nM) on OA-related miRNA expression in primary human articular chondrocytes from female OA patients. b Relative expression of miR-140 in female OA chondrocytes stimulate with different concentration of E2 for 12 hr. c Kinetics of expression of miR-140 expression treated with E2 (10 nM) for 4, 8, 12 and 24 hr in OA chondrocytes from female patients. d E2 induction of miR-140 expression was significantly repressed by estrogen receptor alpha RNAi. Data are represented as mean ± SEM, statistically different from control (* P < 0.05, ** P < 0.001). E2 17-β-estradiol, ERα estrogen receptor alpha

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Arthritis Research & Therapy

ISSN: 1478-6362

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