Fig. 6

Silencing calcium-activated potassium channel KCa1.1β3 but not KCa1.1β1 expression reduces inhibits the invasiveness of fibroblast-like synoviocytes from patients with rheumatoid arthritis (RA-FLS). a K⁺ current density of untransfected RA-FLS and RA-FLS transfected with control small interfering RNA (siRNA) or with siRNA against KCa1.1 β1 before (black) and after treatment with 75 μM lithocholic acid (gray) and normalized to current densities before treatment. Mean ± SEM; n = 3 RA-FLS donors. b Invasiveness of untransfected RA-FLS and RA-FLS transfected with control siRNA, with siRNA against KCa1.1 β3, or with siRNA against KCa1.1 β1. Mean ± SEM; n = 4 RA-FLS donors. *p ≤ 0.5, **p ≤ 0.01, ***p ≤ 0.001