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Table 4 Work productivity activity impairment questionnaire for rheumatoid arthritis (WPAI:RA) results at baseline, week 36, and change from baseline to week 36, according to week-36 concordance category

From: Discordance between patient and physician assessments of global disease activity in rheumatoid arthritis and association with work productivity

All patients

Positive discordance (n = 187)

Concordance (n = 549)

Negative discordance (n = 18)

 
 

Mean (SD)

Median (Q1, Q3)

Mean (SD)

Median (Q1, Q3)

Mean (SD)

Median (Q1, Q3)

P valuea

Activity impairment (n = 754)

Baseline, %

51.1 (20.7)

50.0 (40.0, 70.0)

41.3 (19.2)

40.0 (30.0, 50.0)

42.8 (19.9)

45.0 (30.0, 60.0)

<0.0001

Week 36, %

35.4 (20.8)

30.0 (20.0, 50.0)

15.1 (16.6)

10.0 (0, 20.0)

25.6 (21.2)

20.0 (10.0, 50.0)

<0.0001

Δ Baseline to week 36

−15.7 (24.5)

−10.0 (–30.0, 0)

−26.2 (21.7)

−30.0 (–0.0, –10.0)

−17.2 (25.9)

−10.0 (–30.0, 0)

<0.0001

Employed patients

Positive discordance (n = 76)

Concordance (n = 206)

Negative discordance (n = 5)

 

Mean (SD)

Median (Q1, Q3)

Mean (SD)

Median (Q1, Q3)

Mean (SD)

Median (Q1, Q3)

P valuea

Impairment while working (n = 287)

Baseline, %

50.0 (27.4)

40.0 (30.0, 70.0)

37.8 (25.5)

30.0 (20.0, 50.0)

42.0 (27.7)

50.0 (20.0, 50.0)

0.0026

Week 36, %

26.3 (18.7)

20.0 (20.0, 40.0)

10.7 (13.8)

10.0 (0, 20.0)

12.0 (13.0)

10.0 (0, 20.0)

<0.0001

Δ Baseline to week 36

−23.7 (29.9)

−20.0 (–0.0, 0)

−27.1 (26.4)

−20.0 (–40.0, –10.0)

−30.0 (23.5)

−20.0 (–50.0, –10.0)

<0.0001

Overall work impairment (n = 287)

Baseline, %

54.6 (27.1)

50.0 (33.2, 76.1)

41.5 (27.2)

40.0 (20.0, 60.0)

43.7 (28.6)

50.0 (20.0, 58.3)

0.0019

Week 36, %

28.7 (20.6)

20.0 (20.0, 40.0)

12.2 (15.9)

10.0 (0, 20.0)

12.0 (13.0)

10.0 (0, 20.0)

<0.0001

Δ Baseline to week 36

−25.8 (30.9)

−20.1 (–45.0, –8.6)

−29.3 (27.4)

−22.0 (–46.7, –10.0)

−31.7 (25.4)

−20.0 (–58.3, –10.0)

<0.0001

Employed patients

Positive discordance (n = 74)

Concordance (n = 200)

Negative discordance (n = 5)

 

Mean (SD)

Median (Q1, Q3)

Mean (SD)

Median (Q1, Q3)

Mean (SD)

Median (Q1, Q3)

p valuea

Work time missed (n = 279)

Baseline, %

16.9 (30.2)

0 (0, 17.2)

10.7 (24.3)

0 (0, 6.3)

3.3 (7.5)

0 (0, 0)

0.1565

Week 36, %

5.9 (15.9)

0 (0, 1.8)

2.4 (11.0)

0 (0, 0)

0 (0)

0 (0, 0)

0.2608

Δ Baseline to week 36

−11.0 (30.9)

0 (–10.5, 0)

−8.2 (22.9)

0 (–2.5, 0)

−3.3 (7.5)

0 (0, 0)

0.2608

  1. Activity impairment includes all patients who had both baseline and week 36 data for this parameter. The remaining WPAI parameters include only patients who were employed and had WPAI data at both baseline and week 36. A total of 305 patients were employed at both baseline and week 36; individual WPAI parameters differ due to missing baseline or week 36 values. Positive discordance: patient global assessment – physician global assessment ≥2. Negative discordance: patient global assessment – physician global assessment ≤ –2. Concordance: patient global assessment – physician global assessment = 0 or 1. Δ change; Q1 quartile 1, Q3 quartile 3. a P value for baseline is for one-way analysis of variance, and for week 36 it is for an analysis of covariance model adjusted for baseline of the parameter