Fig. 3
From: Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice
Fewer αSMA-expressing myofibroblasts are observed in the dermis of ETBKO than WT mice after BLM treatment. a Representative images showing the immunohistochemical staining of skin samples for αSMA (upper) and isotype (lower) at 100× magnification. Red arrows indicate myofibroblasts (αSMA-expressing spindle-shaped cells). b Average myofibroblast counts per field of view in the dermis, counted at 100× magnification (* p < 0.05); n = 5–10 mice per group. BLM bleomycin, HPF high-power field, ET B KO endothelin type B receptor knockout, PBS phosphate-buffered saline, WT wild-type