Circulating secretory IgA antibodies against cyclic citrullinated peptides in early rheumatoid arthritis associate with inflammatory activity and smoking

Table 1 Baseline characteristics

Characteristics	TIRA cohorts (n = 636)
Women	426/636 (67.0 %)
Mean age, years (SD)	57.6 (15.0)
Median baseline Larsen score^a (IQR)	2.0 (4.3)
RF-positive	387/636 (60.8 %)
IgG anti-CCP-positive	421/622 (67.7 %)
IgA anti-CCP-positive	251/635 (39.5 %)
SIgA anti-CCP-positive	110/636 (17.3 %)
Median baseline HAQ (IQR)	0.9 (0.6)
Any baseline DMARD	504/631 (79.9 %)

TIRA Swedish acronym for “timely interventions in rheumatoid arthritis”, CCP cyclic citrullinated peptides, RF rheumatoid factor, DMARD disease-modifying antirheumatic drug, IQR interquartile range, IgG immunoglobulin G, IgA immunoglobulin A, SIgA secretory immunoglobulin A, HAQ Health Assessment Questionnaire
Values are number (%) of patients unless otherwise indicated
^aData available from 398 patients

ISSN: 1478-6362