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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis

Fig. 3

Dickkopf-1 (DKK1) gene is downregulated in scleoderma fibroblasts. Rituximab (RTX) treatment upregulates DKK1 gene expression in the skin. Fibroblasts from patients with systemic sclerosis had 4.1-fold downregulation of DKK1 gene expression compared to normal fibroblasts (p < 0.001) (a). RTX treatment mediates significant 4.2-fold upregulation of skin DKK1 gene expression (p = 0.030) (b)

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