Fig. 5From: B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosisUpregulation of Dickkopf-1 (Dkk-1) in skin is associated with enhanced resolution of skin fibrosis. Dkk-1 upregulation following rituximab treatment is associated with a significant decrease in collagen accumulation in the upper dermis compared to patients who did not have upregulation of Dkk-1 (p = 0.040)Back to article page