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Table 4 Comparison of the performance characteristics of enzyme-linked immunosorbent assay (ELISA), line immunoassay (LIA) and lupus anticoagulant (LA) testing of this study investigating 61 patients with APS and 156 controls with previously published data comprising 85 patients with APS and 144 controls [17]

From: Antiphospholipid antibodies detected by line immunoassay differentiate among patients with antiphospholipid syndrome, with infections and asymptomatic carriers

Cohorts   Sensitivity 95 % CI Specificity 95 % CI +LR 95 % CI -LR 95 % CI
61 Patients with APS, 157 controls including 25 asymptomatic carriers ELISA 75.4 62.7–85.5 74.0 66.1–80.9 2.9 2.1–4.0 0.3 0.2–0.5
  LIA* 86.9 75.8–94.2 78.8 71.2–85.1 4.1 3.0–5.7 0.2 0.1–0.3
85 Patients with APS, 144 controls [17] ELISA 58.8 47.6–69.4 95.8 91.1–98.5 14.1 6.3–31.5 0.4 0.3–0.6
  LIA 67.1 56.0–76.9 96.5 92.1–98.9 19.3 8.1–46.3 0.3 0.2–0.5
  1. *Anti-annexin V antibody data for patients with cytomegalovirus infection (n = 10) were excluded. CI confidence interval, LR likelihood ratio