Fig. 1

Rituximab in rheumatoid arthritis patients with moderate (a) or high (b) disease activity at baseline. A possible pragmatic approach following a treat-to-target strategy in the real world. The low-dose (LD) schedule for rituximab is likely appropriate in those with moderate disease activity at baseline, with the conventional dose (CD) in those with high disease activity at baseline. More data are needed on a flexible schedule to be used according to the effective B-cell depletion