Fig. 1

The expression of miR-125b is reduced in peripheral blood mononuclear cells (a) and plasma samples (b) from patients with early rheumatoid arthritis (ERA) compared with healthy controls (HC), and significantly increases after 3 months of therapy (M3), particularly in patients achieving remission or low disease activity (responders), compared to non-responders (c, d). Horizontal line represents the median. P values were estimated using the nonparametric unpaired Mann-Whitney U test to calculate differences in the expression of miR-125b between HC and patients with early RA, and the nonparametric paired Wilcoxon test to calculate differences in the expression of miR-125b between patients with early RA before and after therapy