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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model

Fig. 1

Chondrocytes treated with curcumin exhibits a gene expression profile that is favorable for chondroprotection. Human primary chondrocytes treated with curcumin for 6 hours exhibited reduced mRNA levels of matrix metalloproteinase (MMP)-1, MMP-3, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)5, IL-1β, TNF-α, and increased CITED2 compared to vehicle-treated cells, in the absence (a) and presence (b) of IL-1β, while expression of collagen 2a1 (Col2a1) and aggrecan (Acan) remained unchanged. *P < 0.05, t test, n = 3/group

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