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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model

Fig. 5

Topical application of nano-encapsulated curcumin slowed the progression of OA induced by destabilization of the medial meniscus (DMM) in mice. Mice with DMM were treated daily with topical application of curcumin nanoparticles or vehicle. Mice treated topically with curcumin nanoparticles (Nano-C) exhibited improved Safranin O staining (a), lower Osteoarthritis Research Society International (OARSI) scores (b), and reduced synovitis (c), and subchondral bone plate thickness (d) at 8 weeks after surgery compared to that in vehicle control (Veh) (*p < 0.05, t test, n = 5/group). Representative histologic images are shown

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