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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model

Fig. 6

Topical application of curcumin nanoparticles reduced the degradation of articular cartilage matrix and reduced the expression of matrix metalloproteinase-13 (MMP-13) and a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS5). Intensity of immunohistochemical staining of type II collagen cleavage epitope (Col2-3/4 M) (a) and cleaved aggrecan (NITEGE) (b), and percentage of positive cells of immunohistochemical staining of MMP-13 (c), and of ADAMTS5 (d) in the articular cartilage of mice with destabilization of the medial meniscus (DMM) that were treated with curcumin nanoparticles (N-C) for 8 weeks following surgery were significantly reduced compared to mice with DMM treated with vehicle (Veh) (*p < 0.05, t test, n = 5/group). Scale bar = 100 μM. Representative immunohistochemical images are shown

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