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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Notochordal cell conditioned medium (NCCM) regenerates end-stage human osteoarthritic articular chondrocytes and promotes a healthy phenotype

Fig. 5

Western blot analyses of pellets generated by osteoarthritic (OA) chondrocytes. Data representative of five independent samples of notochordal cell conditioned medium (NCCM)-treated human OA chondrocyte pellets at 14 days of culture compared to controls (CTR). Data are fold-changes normalized to baseline values. a Normalized expression of anabolic proteins. b Normalized expression of catabolic proteins. Representative blots (one of five samples) are shown (c). NCCM significantly increases the levels of anabolic extracellular matrix proteins and the master chrondrogenic regulator sex determining region Y box 9 (SOX9), compared to CTR treatment; *p < 0.05). NCCM significantly decreases the levels of the matrix-degrading matrix metalloproteinase-3 (MMP-3) and MMP-13, and the pro-inflammatory enzyme cyclooxygenase-2 (COX2); *p < 0.05. HAPLN hyaluronic acid link protein

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