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Table 1 Comparison of GAG/DNA accumulation within pellets treated with CTR, Chondroitinsulfate or NCCM medium

From: Notochordal cell conditioned medium (NCCM) regenerates end-stage human osteoarthritic articular chondrocytes and promotes a healthy phenotype

  GAG/DNA pellets (μg/μg)
Baseline 12.1 ± 1.4
14 days of CTR 3.7 ± 1.9
14 days of CS 4.8 ± 0.3
14 days of NCCM 13.4 ± 5.8
  1. Values are mean ± SD. Control (CTR) media comprised 2 % FBS-supplemented advanced DMEM/F-12. The chondroitin sulfate (CS) medium comprised Ctr medium supplemented with 1 mg/mL CS. NCCM was supplemented with 2 % FBS. The accumulation of GAG/DNA in pellets treated with NCCM was clearly superior to CTR and CS, demonstrating that the effects of NCCM are not due to CS. GAG glycosaminoglycan