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Table 1 Descriptive data for the pre-symptomatic individuals, patients with rheumatoid arthritis (RA) and the controls

From: Antibodies directed against endogenous and exogenous citrullinated antigens pre-date the onset of rheumatoid arthritis

  Pre-symptomatic individuals (n = 521) Patients with RA (n = 241) Controls (n = 272)
Female sex, n (%) 371 (71.2) 167 (69.3) 167 (61.4)
Age, mean (SD)a, years 52.4 (9.4) 60.1 (9.7) 51.8 (9.5)
Ever-smoker, n (%) 327/520 (62.9) 162/240 (67.5) 110/266 (41.4)
HLA-SE carrierb, n (%) 249/392 (63.5) 147/218 (67.4) -
PTPN22 1858 T-variant carriage, n (%) 92/262 (35.1) 56/192 (29.2) -
Anti-CCP2 antibody, n (%) 190/518 (36.7) 189/241 (78.4) 7/272 (2.6)
  1. aMean age (standard deviation) calculated for all pre-symptomatic individuals (n = 521) and patients with RA (n = 241). bHLA-DRB1 shared epitope (SE) defined as 0101/0401/0404/0405/0408