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Table 1 Descriptive data for the pre-symptomatic individuals, patients with rheumatoid arthritis (RA) and the controls

From: Antibodies directed against endogenous and exogenous citrullinated antigens pre-date the onset of rheumatoid arthritis

 

Pre-symptomatic individuals (n = 521)

Patients with RA (n = 241)

Controls (n = 272)

Female sex, n (%)

371 (71.2)

167 (69.3)

167 (61.4)

Age, mean (SD)a, years

52.4 (9.4)

60.1 (9.7)

51.8 (9.5)

Ever-smoker, n (%)

327/520 (62.9)

162/240 (67.5)

110/266 (41.4)

HLA-SE carrierb, n (%)

249/392 (63.5)

147/218 (67.4)

-

PTPN22 1858 T-variant carriage, n (%)

92/262 (35.1)

56/192 (29.2)

-

Anti-CCP2 antibody, n (%)

190/518 (36.7)

189/241 (78.4)

7/272 (2.6)

  1. aMean age (standard deviation) calculated for all pre-symptomatic individuals (n = 521) and patients with RA (n = 241). bHLA-DRB1 shared epitope (SE) defined as 0101/0401/0404/0405/0408