Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 1 Patients and disease characteristics

From: Calprotectin and TNF trough serum levels identify power Doppler ultrasound synovitis in rheumatoid arthritis and psoriatic arthritis patients in remission or with low disease activity

Patient characteristics Total (n = 92) RA (n = 42) PsA (n = 50) p Value
Female sex, n (%) 59 (64.1) 34 (81) 25 (50) 0.158
Age, years, median (range) 58 (30–81) 63.5 (30–81) 54.5 (33–77) <0.001
Body index mass, kg/m2, median (range) 26.4 (18–42) 26.2 (19.2–42) 26.6 (18.3–35) 0.189
Disease duration, years, median (range) 15 (1–44) 15.5 (2–44) 14.5 (1–36) 0.785
Presence of erosions, n (%) 53(57.6) 33 (78.6) 20 (40) 0.012
At least one previous biological treatment, n (%) 28 (27) 11 (26) 14 (28) 0.552
Concomitant csDMARD, n (%) 47 (51.1) 32 (76.2) 15 (30) 0.005
Concomitant steroids, n (%) 15 (16.3) 13 (31) 2 (4) <0.001
Prednisone dose, mg/day, median (range) 2.5 (3–5) 2.5 (3–5) 3.7 (3–5) 0.152
Biological treatment duration, months, median (range) 64.8 (12–166) 83.2 (9–165) 58.3 (7.6–166) 0.017
Reduced dosage,a n (%) 42 (45.7) 12 (28.6) 30 (60) <0.001
Albumin, g/dl, median (range) 42.5 (30–49) 32 (30–49) 47 (30–49) 0.005
CRP, mg/dl, median (range) 0.095 (0.01–1.45) 0.10 (0.01–1.4) 0.09 (0.01–0.6) 0.288
ESR, mm/h, median (range) 10 (2–43) 12.5 (2–43) 8.5 (2–32) 0.004
Calprotectin, μg/ml, median (range) 1.67 (0.06–5.54) 2.16 (0.2–5.5) 1.36 (0.06–4.6) 0.002
SJC, median (range) 0 (0–3) 0 (0–3) 0 (0–2) 0.625
TJC, median (range) 0 (0–2) 0 (0–2) 0 (0–1) 0.788
DAS28-ESR, median (range) 1.96 (1.0–3.2) 2.31 (1.3–3.2) 1.82 (1–3.1) <0.001
Remission based on DAS28-ESR, n (%) 71 (77.2) 27 (64.3) 44 (88) 0.005
Low disease activity based on DAS28-ESR, n (%) 21 (22.8) 15 (35.7) 6 (12) 0.005
CDAI, median (range) 6 (2–11.0) 6 (2–11) 6 (2–8) 0.782
SDAI, median (range) 6 (2–11.1) 6 (2–11) 6 (2–8) 0.005
  1. Abbreviations: CDAI Clinical Disease Activity Index, CRP C-reactive protein, csDMARD conventional synthetic disease-modifying anti-rheumatic drug, DAS28-ESR 28-joint Disease Activity Score based on erythrocyte sedimentation rate, ESR erythrocyte sedimentation rate, PsA psoriatic arthritis, RA rheumatoid arthritis, SDAI Simple Disease Activity Index, SJC swollen joint count, TJC tender joint count
  2. aTreatment regimen with a lesser amount of the drug or longer interval of administration than those recommended in the package insert for each product