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Table 2 Changes in expression (cutoff 2-fold) of the genes involved in immune responses and inflammation in patients with polymyositis or dermatomyositis after a median of 8.5 months of immunosuppressive treatment

From: Effects on muscle tissue remodeling and lipid metabolism in muscle tissue from adult patients with polymyositis or dermatomyositis treated with immunosuppressive agents

Gene symbol

Gene

Affy #

Fold change

p

Immune response and antigen presentation

 

 CCL2

chemokine (C-C motif) ligand 2

216598_s_at

–5.9

0.004

 CCL5

chemokine (C-C motif) ligand 5

1405_i_at

–3.0

0.043

 CCR2

chemokine (C-C motif) receptor 2

206978_at

–2.3

0.004

 CCR5

chemokine (C-C motif) receptor 5

206991_s_at

–2.8

0.027

 CD52

CDW52 antigen (CAMPATH-1 antigen)

204661_at

–2.7

0.037

 CD80

CD80 antigen (CD28 ag ligand 1, B7-1 ag)

1554519_at

–2.2

0.034

 CD86

CD86 antigen (CD28 ag ligand 2, B7-2 ag)

210895_s_at

–2.6

0.013

 CHRNA1

cholinergic receptor, nicotinic, αpolypeptide 1

206633_at

–2.8

0.028

 CNPY3

trinucleotide repeat containing 5

1556389_at

–2.1

0.022

 CPM

carboxypeptidase M

206100_at

2.2

0.028

 HLA-DQB1

MHC class II, DQβ2

212998_x_at

–2.0

0.033

 HLA-A

major histocompatibility complex, class I, A

215313_x_at

–2.2

0.012

 HLA-G

HLA-G histocompatibility antigen, class I, G

211530_x_at

–2.3

0.010

 HLA-C

MHC class I, C

208812_x_at

–2.2

0.013

 HLA-B

MHC class I, B

209140_x_at

–2.2

0.017

 HLA-F

MHC class I, F

204806_x_at

–2.6

0.018

 HLA-DQA1

MHC class II, DQα1

203290_at

–2.6

0.036

 HLA-DQB1

MHC class II, DQβ1

209823_x_at

–2.8

0.010

 HLA-DPA1

MHC class II, DPα1

213537_at

–2.9

0.009

 IL-23A

Interleukin 23, subunit alpha

217328_at

–5.2

0.005

 IL-12RB1

Interleukin 12 receptor, beta 1

1552584_at

–2.1

0.020

 NMU

Neuromedin U

206023_at

2.8

0.028

 MMP3

Matrix metalloproteinase 3

205828_at

10.7

0.023

IFN pathway

 STAT1

signal transducer & activator of transcription 1, 91 kDa

209969_s_at

–3.3

0.008

 CXCL10

chemokine (C-X-C motif) ligand 10

204533_at

–5.6

0.020

 CXCL11

chemokine (C-X-C motif) ligand 11

211122_s_at

–5.6

0.015

 RTP4

28kD interferon responsive protein

219684_at

–5.7

0.028

 IRF8

IFN consensus sequence binding protein 1

204057_at

–2.4

0.033

 ISG20

IFN stimulated gene 20 kDa

204698_at

–5.8

0.029

 IFI6

IFNα-inducible protein

204415_at

–4.7

0.045

 IFI30

IFNγ-inducible protein 30

201422_at

–2.2

0.036

 IFI35

IFN -induced protein 35

209417_s_at

–2.6

0.036

 IFIT3

IFN -induced protein w tetratricopeptide repeats 4

229450_at

–5.1

0.032

 IRF9

IFN -stimulated transcription factor 3, γ

203882_at

–3.8

0.005

 GBP1

guanylate binding protein 1, IFN-inducible

202269_x_at

–2.9

0.009

 GBP2

guanylate binding protein 1, IFN-inducible

242907_at

–2.7

0.005

 GBP5

guanylate binding protein 5

238581_at

–2.1

0.017

Inflammasome

 AIM2

absent in melanoma 2

206513_at

–2.5

0.008

 CASP1

caspase 1, (interleukin 1β convertase)

211367_s_at

–2.3

0.009

 IL18

interleukin 18 (IFNg-inducing factor)

206295_at

–2.2

0.042

Eicosanoids

 PTGER3

prostaglandin E receptor 3 (subtype EP3)

210832_x_at

3.0

0.013

 PTGER4

prostaglandin E receptor 4 (subtype EP4)

204897_at

–2.0

0.027

 CYSLTR1

cysteinyl leukotriene receptor 1

230866_at

–2.8

0.037