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Table 2 Changes in expression (cutoff 2-fold) of the genes involved in immune responses and inflammation in patients with polymyositis or dermatomyositis after a median of 8.5 months of immunosuppressive treatment

From: Effects on muscle tissue remodeling and lipid metabolism in muscle tissue from adult patients with polymyositis or dermatomyositis treated with immunosuppressive agents

Gene symbol Gene Affy # Fold change p
Immune response and antigen presentation  
 CCL2 chemokine (C-C motif) ligand 2 216598_s_at –5.9 0.004
 CCL5 chemokine (C-C motif) ligand 5 1405_i_at –3.0 0.043
 CCR2 chemokine (C-C motif) receptor 2 206978_at –2.3 0.004
 CCR5 chemokine (C-C motif) receptor 5 206991_s_at –2.8 0.027
 CD52 CDW52 antigen (CAMPATH-1 antigen) 204661_at –2.7 0.037
 CD80 CD80 antigen (CD28 ag ligand 1, B7-1 ag) 1554519_at –2.2 0.034
 CD86 CD86 antigen (CD28 ag ligand 2, B7-2 ag) 210895_s_at –2.6 0.013
 CHRNA1 cholinergic receptor, nicotinic, αpolypeptide 1 206633_at –2.8 0.028
 CNPY3 trinucleotide repeat containing 5 1556389_at –2.1 0.022
 CPM carboxypeptidase M 206100_at 2.2 0.028
 HLA-DQB1 MHC class II, DQβ2 212998_x_at –2.0 0.033
 HLA-A major histocompatibility complex, class I, A 215313_x_at –2.2 0.012
 HLA-G HLA-G histocompatibility antigen, class I, G 211530_x_at –2.3 0.010
 HLA-C MHC class I, C 208812_x_at –2.2 0.013
 HLA-B MHC class I, B 209140_x_at –2.2 0.017
 HLA-F MHC class I, F 204806_x_at –2.6 0.018
 HLA-DQA1 MHC class II, DQα1 203290_at –2.6 0.036
 HLA-DQB1 MHC class II, DQβ1 209823_x_at –2.8 0.010
 HLA-DPA1 MHC class II, DPα1 213537_at –2.9 0.009
 IL-23A Interleukin 23, subunit alpha 217328_at –5.2 0.005
 IL-12RB1 Interleukin 12 receptor, beta 1 1552584_at –2.1 0.020
 NMU Neuromedin U 206023_at 2.8 0.028
 MMP3 Matrix metalloproteinase 3 205828_at 10.7 0.023
IFN pathway
 STAT1 signal transducer & activator of transcription 1, 91 kDa 209969_s_at –3.3 0.008
 CXCL10 chemokine (C-X-C motif) ligand 10 204533_at –5.6 0.020
 CXCL11 chemokine (C-X-C motif) ligand 11 211122_s_at –5.6 0.015
 RTP4 28kD interferon responsive protein 219684_at –5.7 0.028
 IRF8 IFN consensus sequence binding protein 1 204057_at –2.4 0.033
 ISG20 IFN stimulated gene 20 kDa 204698_at –5.8 0.029
 IFI6 IFNα-inducible protein 204415_at –4.7 0.045
 IFI30 IFNγ-inducible protein 30 201422_at –2.2 0.036
 IFI35 IFN -induced protein 35 209417_s_at –2.6 0.036
 IFIT3 IFN -induced protein w tetratricopeptide repeats 4 229450_at –5.1 0.032
 IRF9 IFN -stimulated transcription factor 3, γ 203882_at –3.8 0.005
 GBP1 guanylate binding protein 1, IFN-inducible 202269_x_at –2.9 0.009
 GBP2 guanylate binding protein 1, IFN-inducible 242907_at –2.7 0.005
 GBP5 guanylate binding protein 5 238581_at –2.1 0.017
Inflammasome
 AIM2 absent in melanoma 2 206513_at –2.5 0.008
 CASP1 caspase 1, (interleukin 1β convertase) 211367_s_at –2.3 0.009
 IL18 interleukin 18 (IFNg-inducing factor) 206295_at –2.2 0.042
Eicosanoids
 PTGER3 prostaglandin E receptor 3 (subtype EP3) 210832_x_at 3.0 0.013
 PTGER4 prostaglandin E receptor 4 (subtype EP4) 204897_at –2.0 0.027
 CYSLTR1 cysteinyl leukotriene receptor 1 230866_at –2.8 0.037