Table 3 Changes in expression (cutoff 2-fold) of genes involved in ubiquitin proteasome pathway, skeletal muscle structure, and remodeling in patients with polymyositis or dermatomyositis after immunosuppressive treatment
Gene symbol | Gene | Affy # | Fold change | p |
|---|---|---|---|---|
Ubiquitin proteasome pathway | ||||
 PSMB8 | proteasome subunit,β type, 8 (large multifunctional protease 7) | 209040_s_at | –6.6 | 0.003 |
 UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 201649_at | –2.8 | 0.032 |
 PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 204279_at | –2.4 | 0.005 |
 PSME1 | proteasome) activator subunit 1 (PA28 α) | 200814_at | –2.3 | 0.007 |
 PSME2 | proteasome activator subunit 2 (PA28β) | 201762_s_at | –2.0 | 0.012 |
 CNTN3 | ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) | 229831_at | 2.4 | 0.029 |
Structure proteins and tissue remodeling | ||||
 MYBPH | myosin binding protein H | 206304_at | –6.9 | 0.036 |
 RRAD | Ras-related associated with diabetes | 204803_s_at | –3.2 | 0.013 |
 BMP1 | bone morphogenetic protein 1 | 207595_s_at | –2.7 | 0.001 |
 NCOA6 | Nuclear receptor co-activator | 1568874_at | –3.0 | 0.041 |
 CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | 1555993_at | –2.9 | 0.035 |
 CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 226368_at | –2.1 | 0.009 |
 MYH4 | myosin, heavy polypeptide 4, skeletal muscle | 208148_at | 2.2 | 0.020 |
 FOXO1 | forkhead box O1A | 202723_s_at | 2.3 | 0.026 |
 MSTN | growth differentiation factor 8 | 207145_at | 2.3 | 0.041 |
 VCL | vinculin | 200930_s_at | 2.4 | 0.022 |
 TIMP4 | tissue inhibitor of metalloproteinase 4 | 206243_at | 2.6 | 0.024 |
 FKBP5 | FK506 binding protein 5 | 204560_at | 3.4 | 0.015 |
 ACTN3 | actinin, alpha 3 | 206891_at | 3.4 | 0.037 |