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Table 3 Changes in expression (cutoff 2-fold) of genes involved in ubiquitin proteasome pathway, skeletal muscle structure, and remodeling in patients with polymyositis or dermatomyositis after immunosuppressive treatment

From: Effects on muscle tissue remodeling and lipid metabolism in muscle tissue from adult patients with polymyositis or dermatomyositis treated with immunosuppressive agents

Gene symbol Gene Affy # Fold change p
Ubiquitin proteasome pathway
 PSMB8 proteasome subunit,β type, 8 (large multifunctional protease 7) 209040_s_at –6.6 0.003
 UBE2L6 ubiquitin-conjugating enzyme E2L 6 201649_at –2.8 0.032
 PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 204279_at –2.4 0.005
 PSME1 proteasome) activator subunit 1 (PA28 α) 200814_at –2.3 0.007
 PSME2 proteasome activator subunit 2 (PA28β) 201762_s_at –2.0 0.012
 CNTN3 ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) 229831_at 2.4 0.029
Structure proteins and tissue remodeling
 MYBPH myosin binding protein H 206304_at –6.9 0.036
 RRAD Ras-related associated with diabetes 204803_s_at –3.2 0.013
 BMP1 bone morphogenetic protein 1 207595_s_at –2.7 0.001
 NCOA6 Nuclear receptor co-activator 1568874_at –3.0 0.041
 CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 1555993_at –2.9 0.035
 CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 226368_at –2.1 0.009
 MYH4 myosin, heavy polypeptide 4, skeletal muscle 208148_at 2.2 0.020
 FOXO1 forkhead box O1A 202723_s_at 2.3 0.026
 MSTN growth differentiation factor 8 207145_at 2.3 0.041
 VCL vinculin 200930_s_at 2.4 0.022
 TIMP4 tissue inhibitor of metalloproteinase 4 206243_at 2.6 0.024
 FKBP5 FK506 binding protein 5 204560_at 3.4 0.015
 ACTN3 actinin, alpha 3 206891_at 3.4 0.037