Table 4 Changes in expression of the genes involved in lipid metabolism in patients with polymyositis or dermatomyositis after immunosuppressive treatment
Gene symbol | Gene | Affy # | Fold change | p |
|---|---|---|---|---|
Lipid transport and uptake | ||||
 FABP7 | fatty acid binding protein 7, brain | 205029_s_at | 10.0 | 0.002 |
 ABCD2 | ATP-binding cassette, sub-family D member 2 | 207583_at | 4.55 | 0.043 |
 APOL6 | apolipoprotein L, 6 | 241869_at | –3.12 | 3.14E-05 |
Lipid accumulation and lipolysis | ||||
 SCD | stearoyl-CoA desaturase (delta-9) | 223839_s_at | 3.86 | 0.042 |
 CIDEC | cell death-inducing DFFA-like effector c | 219398_at | 3.53 | 0.049 |
 CERS3 | ceramide synthase 3 | 1554252_a_at | 3.2 | 0.021 |
 CES1 | carboxylesterase 1 | 209616_s_at | 2.98 | 0.028 |
 MSTN | myostatin | 207145_at | 2.28 | 0.041 |
 CNR1 | Human CB1 cannabinoid receptor | 213436_at | 2.14 | 0.009 |
 LPL | lipoprotein lipase | 203549_s_at | 2.05 | 0.022 |
 LIPE | lipase, hormone-sensitive | 213855_s_at | 2.00 | 0.034 |
 ACSL3 | fatty-acid-Coenzyme A ligase, long-chain 3 | 236168_at | –3.87 | 0.048 |
 LSDP5 | Lipid Storage Droplet Protein 5 | 1560457_x_at | –2.61 | 0.030 |
 SPHK1 | sphingosine kinase 1 | 219257_s_at | –2.20 | 0.037 |