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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages

Fig. 2

Histological analysis of inflamed joints in mice with collagen-induced arthritis (CIA). a The severity of arthritis was evaluated histologically in knee and ankle joint specimens obtained from control CIA mice (untreated) and mice treated with different dosages of soluble sialic acid-binding immunoglobulin-type lectin (sSiglec)-9. Each section was stained with hematoxylin and eosin (HE; upper row) or Safranin O (lower row). Serial sagittal sections (4.5 μm) were examined, and the maximally affected section was evaluated and scored. Typically, the midline of the medial condyle was examined. Scale bar = 100 μm. be Mean ± SEM histological arthritis scores (inflammation, pannus formation, cartilage degeneration, and bone erosion) in control CIA mice and mice treated with different dosages of sSiglec-9. *p < 0.05, ** p < 0.01 (Bonferroni post hoc test)

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