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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Mast cell depletion in the preclinical phase of collagen-induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile

Fig. 1

Depletion of FcεRIβ+-cells in clinical phase of CIA does not influence clinical outcome in RMB-DBA/1 mice. a Progression of CIA was monitored by clinical scoring of RMB-DBA/1 mice injected with either PBS or DT (n = 15/group). b Serum levels of IgG1, IgG2a, IgG2c and IgE isotype antibodies directed against collagen type II were quantified in serum from PBS- or DT-injected RMB-DBA/1 mice (n = 15/group). c Mast cell numbers were determined in ankle joints of PBS- and DT-treated mice (n = 15/group). Arrows show mast cells in the joint. d FACS analysis for common peripheral leucocytes in both groups (*** p < 0.001) A representative example of two independent experiments is depicted. DT diphtheria toxin, IgE immunoglobulin E, IgG immunoglobulin G, PBS phosphate-buffered saline

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