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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Mast cell depletion in the preclinical phase of collagen-induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile

Fig. 5

Altered CD4+T cell phenotype in spleen and enhanced anti-inflammatory response toward collagen type II of splenocytes from FcεRIβ+ cell-depleted mice. a Splenocytes from PBS- and DT-injected RMB-DBA/1 mice were stained intracellularly for IL-17 after stimulation with anti-CD3/28 (n = 15/group). b Splenocytes from PBS- and DT-injected RMB-DBA/1 mice were stained intracellularly for FoxP3. (n = 15/group). c Cytokine release of splenocytes from PBS- or DT-injected RMB-DBA/1 mice after restimulation with either αCD3/28 or collagen type II (n = 15/group). (* p < 0.05). A representative example of two independent experiments is depicted. DT diphtheria toxin, IFN interferon, IL interleukin, PBS phosphate-buffered saline, TNF-α tumor necrosis factor

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