Fig. 2

CIA development in LNT-Igk-Ctrl and LNT-Igk-CII mice. a Arthritis frequency and b clinical severity after CIA induction in LNT-Igk-Ctrl and LNT-Igk-CII mice. c Histopathological evaluation of synovitis and joint erosions at day 40 after CIA induction (n = 10 per group, one of three experiments is shown). Indicated P values were determined using Fisher’s exact test for nominal data, linear regression to compare the severity of arthritis (shown as mean ± SD) and a non-parametric test for categorical data. *P < 0.05; **P < 0.01; ***P < 0.001