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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Nuclear factor erythroid 2-related factor 2 is a critical target for the treatment of glucocorticoid-resistant lupus nephritis

Fig. 3

Prevention of development of kidney diseases upon administration of DMF in pristane-injected mice. (ad) Representative microphotograms of renal tissue obtained from PBS/0.5 % methylcellulose (sham)-treated (a), pristane/0.5 % methylcellulose (vehicle)-treated (b), pristane/DMF-treated (c), and pristane/prednisolone-treated (d) mice (PAS staining). Scale bar, 200 μm. (e) Glomerulonephritis score of pristane-induced LN of the four groups of mice at the experimental end point. *p < 0.05 by Dunnett’s nonparametric test performed versus sham-treated group. (f) At 20 weeks after pristane injection, the urine albumin-to-creatinine ratio (uACR) was measured. **p < 0.01 by Dunnett’s parametric test performed versus sham-treated group. n = 5–7 animals per group. DMF dimethyl fumarate

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