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Table 1 Effects of Nrf2 activators and prednisolone on MCP-1 and IL-6 production in TNF-α-stimulated HRMCsa

From: Nuclear factor erythroid 2-related factor 2 is a critical target for the treatment of glucocorticoid-resistant lupus nephritis

IC50 (μM) MCP-1 IL-6
DMF 8.8 12.2
Sulforaphane 2.0 3.9
Prednisolone >100 >100
  1. aConcentrations of 50 % inhibition (IC 50 ) of MCP-1 and IL-6 production were calculated from sigmoidal inhibition curves presented in Fig. 3. The IC50 values were obtained from three individuals
  2. DMF dimethyl fumarate, HRMC human renal mesangial cell, IL-6 interleukin-6, MCP-1 monocyte chemoattractant protein-1, Nrf2 nuclear factor erythroid 2-related factor 2, TNF-α tumor necrosis factor alpha
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Arthritis Research & Therapy

ISSN: 1478-6362

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