IC50 (μM)
|
MCP-1
|
IL-6
|
---|
DMF
|
8.8
|
12.2
|
Sulforaphane
|
2.0
|
3.9
|
Prednisolone
|
>100
|
>100
|
-
aConcentrations of 50 % inhibition (IC
50
) of MCP-1 and IL-6 production were calculated from sigmoidal inhibition curves presented in Fig. 3. The IC50 values were obtained from three individuals
-
DMF dimethyl fumarate, HRMC human renal mesangial cell, IL-6 interleukin-6, MCP-1 monocyte chemoattractant protein-1, Nrf2 nuclear factor erythroid 2-related factor 2, TNF-α tumor necrosis factor alpha