Nuclear factor erythroid 2-related factor 2 is a critical target for the treatment of glucocorticoid-resistant lupus nephritis

Table 1 Effects of Nrf2 activators and prednisolone on MCP-1 and IL-6 production in TNF-α-stimulated HRMCs^a

^aConcentrations of 50 % inhibition (IC ₅₀) of MCP-1 and IL-6 production were calculated from sigmoidal inhibition curves presented in Fig. 3. The IC₅₀ values were obtained from three individuals
DMF dimethyl fumarate, HRMC human renal mesangial cell, IL-6 interleukin-6, MCP-1 monocyte chemoattractant protein-1, Nrf2 nuclear factor erythroid 2-related factor 2, TNF-α tumor necrosis factor alpha