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Table 1 Dialysate and plasma levels (pg/mL) of cytokines as well as frequency (%) of detectable samples in 24 patients with fibromyalgia (FMS) and 27 healthy controls (CON) before and after 15 weeks of resistance exercise twice per week, as well as the P value for within-group comparison (Wilcoxon test)

From: Effects of 15 weeks of resistance exercise on pro-inflammatory cytokine levels in the vastus lateralis muscle of patients with fibromyalgia

   FMS P value CON P value
   Before After   Before After  
IL-1β       
 Dialysate        
  Detectable 48 44   41 34  
  Level 0.10 (0.13) 0.05 (0.16) 0.522 0.06 (0.17) 0.01 (0.16) 0.479
 Plasma       
  Detectable 70 83   89 96  
  Level 1.13 (3.55) 1.23 (1.86) 0.823 1.23 (1.40) 1.54 (1.33) 0.845
IL-6       
 Dialysate       
  Detectable 97 95   98 100  
  Level 81.1 (131.7) 100.4 (236.3) 0.540 156.4 (196.9) 107.0 (173.5) 1.000
 Plasma       
  Detectable 91 100   96 96  
  Level 1.60 (1.48) 2.35 (2.14)* 0.831 1.31 (1.43) 1.41 (1.24) 0.556
IL-8       
 Dialysate       
  Detectable 95 91   98 99  
  Level 37.5 (75.6) 42.2 (71.6) 0.838 61.0 (101.4) 61.7 (58.0) 1.000
 Plasma       
  Detectable 91 87   74 78  
  Level 1.66 (2.10)* 1.22 (3.19) 0.136 0.47 (1.61) 0.56 (1.11) 1.000
TNF       
 Dialysate       
  Detectable 67# 67#   93 94  
  Level 0.16 (0.18)* 0.19 (0.25)* 0.831 0.27 (0.23) 0.26 (0.17) 0.556
 Plasma       
  Detectable 100 100   100 100  
  Level 4.27 (1.70) 3.79 (3.67) 0.831 3.72 (2.68) 3.56 (2.31) 1.000
  1. The dialysate levels represent the average of 5 samples obtained during microdialysis (140-220 min), which included 20 min of dynamic exercise. Dialysate and plasma levels are presented as median (interquartile range)
  2. Between-group comparisons: *P < 0.05 (Mann-Whitney U test) # P < 0.001 (Chi square test)
  3. IL interleukin, TNF tumor necrosis factor beta