Fig. 5
From: Collagen-induced arthritis and imiquimod-induced psoriasis develop independently of interleukin-33
Clinical and histological evaluation of imiquimod (IMQ)-induced skin inflammation in mice. C57BL/6 mice, interleukin (IL)-33-/- and wild-type (WT), were daily treated with IMQ cream or vehicle cream (Vaseline), applied on the shaved back skin. Phenotypical presentation of mouse back skin after shaving and before cream application showed a thin and white skin without scales (a). These characteristics were maintained 4 days after Vaseline application (b). In contrast, IMQ-treated mice showed erythema, infiltration, and scales, which appeared at day 4 in both IL-33-/- (c) and WT (d) mice. Skin inflammation was increased similarly in both groups, with more scales and increased infiltration at day 9 in both IL-33-/- (e) and WT (f) mice. Histological slides (×200) of back skin 11 days after IMQ application in IL-33-/- mice (g) and WT mice (h) showed acanthosis and hyperkeratosis. Control WT mice without IMQ application is shown in (i)