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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Interaction among activated lymphocytes and mesenchymal cells through podoplanin is critical for a high IL-17 secretion

Fig. 4

Role of monocytes on pro-inflammatory cytokine production. Healthy PBMC or Th17 clones were cultured alone or in co-culture with RA synoviocytes at a 5:1 ratio or 1:1 ratio, respectively, for 48 h, in the presence or absence of PHA (5 μg/ml), and monocytes were removed or not by adherence before culture. Production of IL-1β (a, d), IL-6 (b, e) and IL-17 (c, f) were measured in supernatants after 48 h, by ELISA. *Compared conditions with and without monocytes. * p ≤ 0.05. IL interleukin, PBMC peripheral blood mononuclear cells, PHA phytohemagglutinin, RA rheumatoid arthritis

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