Concurrent validity of different functional and neuroproteomic pain assessment methods in the rat osteoarthritis monosodium iodoacetate (MIA) model

Table 3 Coefficient of variation (CV) for each outcome and variation in CV between four protocols of acclimatization

	8 Days		6 Days		5 Days		4 Days
Functional evaluation^a	CV (D-14)	CV* ratio	CV (D-14)	CV* ratio	CV (D-14)	CV* ratio	CV (D-14)	CV* ratio
SWB	17.3	0 . 72	31.2	0 . 30	11.7	0 . 62	12.2	0 . 67
PEAP	23.8	1.01	24.1	1.07	21.3	0.97	22.8	1.11
TS	42.9	0 . 85	22.9	1.24	20.4	1.01	27.4	1.80
TNTC	36.9	1.10	106.5	0 . 54	31.2	0.91	38.0	1.92
MS	63.3	0 . 74	71.8	1.07	72.2	0 . 71	75.3	0 . 53

^aThe functional evaluation includes the values recorded for the right hind limb, when available (static weight bearing (SWB), tactile sensitivity (TS), mechanical sensitivity (MS)), or the response of the animal (place escape/avoidance paradigm (PEAP) and treadmill number of total crossings (TNTC)). *The CV values calculated on day -1 were normalized to the CV values on day -14 (D-14) to test the influence of the acclimatization protocol on the outcome measures. A day -1/day -14 CV ratio value <1 was indicative of improvement in variability and is presented in bold italics

ISSN: 1478-6362