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Table 3 Coefficient of variation (CV) for each outcome and variation in CV between four protocols of acclimatization

From: Concurrent validity of different functional and neuroproteomic pain assessment methods in the rat osteoarthritis monosodium iodoacetate (MIA) model

  8 Days 6 Days 5 Days 4 Days
Functional evaluationa CV (D-14) CV* ratio CV (D-14) CV* ratio CV (D-14) CV* ratio CV (D-14) CV* ratio
SWB 17.3 0 . 72 31.2 0 . 30 11.7 0 . 62 12.2 0 . 67
PEAP 23.8 1.01 24.1 1.07 21.3 0.97 22.8 1.11
TS 42.9 0 . 85 22.9 1.24 20.4 1.01 27.4 1.80
TNTC 36.9 1.10 106.5 0 . 54 31.2 0.91 38.0 1.92
MS 63.3 0 . 74 71.8 1.07 72.2 0 . 71 75.3 0 . 53
  1. aThe functional evaluation includes the values recorded for the right hind limb, when available (static weight bearing (SWB), tactile sensitivity (TS), mechanical sensitivity (MS)), or the response of the animal (place escape/avoidance paradigm (PEAP) and treadmill number of total crossings (TNTC)). *The CV values calculated on day -1 were normalized to the CV values on day -14 (D-14) to test the influence of the acclimatization protocol on the outcome measures. A day -1/day -14 CV ratio value <1 was indicative of improvement in variability and is presented in bold italics