Fig. 1

American College of Rheumatology (ACR) response rates 3 months before switch, at switch, and 3 months after switch*. ADA adalimumab, BID twice daily. *Includes patients who completed treatment with ADA 40 mg Q2W or tofacitinib 10 mg BID in ORAL Standard (or discontinued treatment for reasons other than a tofacitinib-related serious AE) and then enrolled in ORAL Sequel and switched treatment with minimal washout (≤2 weeks after their last dose of study drug in ORAL Standard). ACR, American College of Rheumatology; ACR20/50/70, 20/50/70% reduction in the number of tender and swollen joints, as well as 20/50/70% improvement in ≥3 of the other five ACR components; ADA, adalimumab; BID, twice daily; Q2W, every 2 weeks