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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Whole-genome transcription and DNA methylation analysis of peripheral blood mononuclear cells identified aberrant gene regulation pathways in systemic lupus erythematosus

Fig. 5

Upregulated genes in PBMC of SLE were significantly enriched in the toll-like receptor signaling pathway. a A diagram showing the toll-like receptor signaling pathway and upregulated genes involved in the network. b Array-based mRNA expression represented by normalized intensity in SLE LN+, SLE LN, and normal controls.*Indicates p < 0.05 as compared to normal controls. c The CpG sites in EIF2AK2 and IRAK3 genes were hypomethylated in SLE patients compared with NC. *Indicates p < 0.05. NC normal controls, SLE systemic lupus erythematosus, SLE LN + SLE with lupus nephritis, SLE LN SLE without lupus nephritis

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