Fig. 5From: Whole-genome transcription and DNA methylation analysis of peripheral blood mononuclear cells identified aberrant gene regulation pathways in systemic lupus erythematosusUpregulated genes in PBMC of SLE were significantly enriched in the toll-like receptor signaling pathway. a A diagram showing the toll-like receptor signaling pathway and upregulated genes involved in the network. b Array-based mRNA expression represented by normalized intensity in SLE LN+, SLE LN−, and normal controls.*Indicates p < 0.05 as compared to normal controls. c The CpG sites in EIF2AK2 and IRAK3 genes were hypomethylated in SLE patients compared with NC. *Indicates p < 0.05. NC normal controls, SLE systemic lupus erythematosus, SLE LN + SLE with lupus nephritis, SLE LN − SLE without lupus nephritisBack to article page