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Fig. 7 | Arthritis Research & Therapy

Fig. 7

From: Whole-genome transcription and DNA methylation analysis of peripheral blood mononuclear cells identified aberrant gene regulation pathways in systemic lupus erythematosus

Fig. 7

Quantification of 27 cytokines and chemokines in sera of SLE patients and controls using bead-based multiplex assays. a Seventeen cytokines showed significant difference in SLE patients compared with NC, 15 were increased and two were decreased in both SLE LN and SLE LN+ compared with NC (* p < 0.05). b mRNA expression level in PBMC for the cytokines which showed significant difference in sera of SLE patients. IL-15 mRNA was significantly upregulated and CCL5 mRNA were downregulated in PBMC of SLE patients compared with NC (* p < 0.05). c Six CpG sites in the IL-15 gene were hypomethylated and three CpG sites in CCL5 (RANTES) gene were hypomethylated in PBMC of SLE compared with NC. (* p < 0.05). NC normal controls, SLE systemic lupus erythematosus, SLE LN + SLE with lupus nephritis, SLE LN SLE without lupus nephritis

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