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Table 1 Clinical manifestation and laboratory data of SLE patients and normal controls

From: Whole-genome transcription and DNA methylation analysis of peripheral blood mononuclear cells identified aberrant gene regulation pathways in systemic lupus erythematosus

Clinical characteristics NC (n = 25) SLE LN (n = 15) SLE LN+ (n = 15) p valued
SLE LN vs. NC SLE LN+ vs. NC SLE LN+ vs. SLE LN
Age (mean + SD) 32.2 ± 9.04 28.2 ± 6.7 30.13 ± 7.68 n.s. n.s. n.s.
Sex (M/F) 5/20 2/13 2/13 n.s. n.s. n.s.
Disease duration (months) - 4.90 ± 4.18 3.33 ± 4.21 - - n.s.
SLEDAI - 9.06 ± 4.06 14.93 ± 4.65 - - 0.001
1997 ACR classification criteria for SLE
 Malar rash - 8 11 - - -
 Discoid rash - 1 3 - - -
 Photosensitivity - 4 3 - - -
 Oral ulcers - 2 1 - - -
 Nonerosive arthritis - 8 6 - - -
 Pleuritis or pericarditis - 1 3 - - -
 Renal disorder - 0 15 - - -
 Neurological disorder - 1 0 - - -
 Hematological disorder - 2 7 - - -
 Immunological disorder - 11 12 - - -
 Positive antinuclear antibody (ANA) - 15 14 - - -
WBC (×109/L)a - 6.64 ± 0.70 6.45 ± 0.90 -   0.866
Neutrophils (×109/L)b - 5.00 ± 0.69 4.74 ± 0.76 -   0.799
Lymphocytes (×109/L)c - 1.54 ± 0.21 1.22 ± 0.18 -   0.246
C3 (mg/dL) - 534.5 ± 280.1 293.2 ± 196.2 -   0.0108
C4 (mg/dL) - 133.2 ± 147.4 88.02 ± 86.48 -   0.3145
  1. There were no significant difference in age and gender between normal controls and SLE. SLE LN+ patients exhibited higher disease activity (SLEDAI score) and lower level of complement C3 than SLE LN-. Complete blood count (CBC) in SLE patients showed that the count of white blood cells (WBC), neutrophils, and lymphocytes are within the normal range in SLE patients
  2. SLE systemic lupus erythematosus, NC normal controls, SLE LN + SLE with lupus nephritis, SLE LN SLE without lupus nephritis, SLEDAI SLE Disease Activity Index, n.s. not significant, ACR American College of Rheumatology, C3 complement component 3, C4 complement component 4
  3. aNormal range of white blood cell (WBC) count: 3.5–10.5 × 109/L
  4. bNormal range of neutrophils: 2.0–7.0 × 109/L
  5. cNormal range of lymphocytes: 1.0–3.0 × 109/L
  6. d t test, p < 0.05 means significant