Skip to main content

Advertisement

Table 1 Strongest positive and negative correlation between the most expressed messenger RNA (top upregulated and downregulated genes) and miR-155/miR-21/miR-4459 lung expression

From: miR-155 in the progression of lung fibrosis in systemic sclerosis

Abbreviation Gene name Fold-change r (miR-155) r (miR-21) r (miR-4459)
MMP1 Matrix metallopeptidase 1 (interstitial collagenase) 14.1 0.13 0.24 -0.52
MMP7 Matrix metallopeptidase 7 (matrilysin, uterine) 12.0 0.57 0.54 -0.85
KRT15 Keratin 15 7.1 0.27 0.40 -0.51
S100A2 S100 calcium binding protein A2 6.6 0.29 0.45 -0.57
PDIA3 Protein disulfide isomerase family A, member 3 6.2 0.67 0.52 -0.76
CDH3 Cadherin 3, type 1, P-cadherin (placental) 5.6 0.60 0.60 -0.82
IL13RA2 Interleukin 13 receptor, alpha 2 5.6 0.75 0.81 -0.78
IGHM Immunoglobulin heavy constant mu 5.5 0.67 0.52 -0.63
SPP1 Secreted phosphoprotein 1 5.1 0.69 0.55 -0.74
GPR87 G protein-coupled receptor 87 4.7 0.29 0.32 -0.45
RRM2 Ribonucleotide reductase M2 4.7 0.72 0.59 -0.57
CTSE Cathepsin E 4.4 0.66 0.66 -0.91
AADAC Arylacetamide deacetylase 4.4 0.60 0.48 -0.76
CXCL6 Chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 4.3 0.34 0.34 -0.30
CR2 Complement component (3d/Epstein Barr virus) receptor 2 4.2 0.61 0.37 -0.42
TYMS Thymidylate synthetase 4.2 0.72 0.58 -0.75
CXCL13 Chemokine (C-X-C motif) ligand 13 4.1 0.77 0.59 -0.48
SCG5 Secretogranin V (7B2 protein) 4.1 0.76 0.70 -0.70
MEOX1 Mesenchyme homeobox 1 3.9 0.59 0.52 -0.51
TOP2A Topoisomerase (DNA) II alpha 170 kDa 3.7 0.68 0.62 -0.64
POSTN Periostin, osteoblast specific factor 3.7 0.74 0.70 -0.74
  Pearson’s correlation >0.5 or < -0.5 total n = 16 n = 14 n = 17
IL6 Interleukin 6 (interferon, beta 2) -45.2 -0.50 -0.44 0.54
SERPINE1 Plasminogen activator inhibitor type 1, member 1 -21.9 -0.45 -0.36 0.60
FOSB FBJ murine osteosarcoma viral oncogene homolog B -18.4 -0.69 -0.66 0.73
MT1M Metallothionein 1 M -15.8 -0.50 -0.41 0.54
DDX3Y DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked -14.3 -0.17 -0.51 0.33
RND1 Rho family GTPase 1 -13.6 -0.46 -0.37 0.40
IL8 Interleukin 8 -12.8 -0.40 -0.26 0.37
NXF3 Nuclear RNA export factor 3 -12.0 -0.80 -0.75 0.89
CSF3 Colony stimulating factor 3 (granulocyte) -11.8 -0.50 -0.34 0.48
CCL2 Chemokine (C-C motif) ligand 2 -11.6 -0.47 -0.36 0.54
PTX3 Pentraxin 3, long -11.4 -0.15 -0.02 0.27
IL12A Interleukin 12A -11.1 -0.70 -0.64 0.85
CCL20 Chemokine (C-C motif) ligand 20 -9.5 -0.25 -0.17 0.15
GADD45B Growth arrest and DNA-damage-inducible, beta -9.5 -0.50 -0.42 0.54
ESM1 Endothelial cell-specific molecule 1 -8.6 -0.52 -0.36 0.48
CXCL2 Chemokine (C-X-C motif) ligand 2 -8.5 -0.40 -0.44 0.46
SLC6A4 Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 -8.4 -0.82 -0.87 0.72
SLCO4A1 Solute carrier organic anion transporter family, member 4A1 -8.3 -0.62 -0.50 0.64
KDM5D Lysine (K)-specific demethylase 5D -8.2 -0.15 -0.48 0.37
S100A12 S100 calcium binding protein A12 -8.2 -0.45 -0.33 0.53
HAS2 Hyaluronan synthase 2 -8.2 -0.29 -0.27 0.30
  Pearson’s correlation >0.5 or < –0.5 total n = 9 n = 6 n = 10
  1. In sequence: gene symbol, gene name, average fold-change expression in SSc-ILD compared to healthy controls, r values for correlation between each gene and specific miRNA