Table 2 Top 10 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways related to the most expressed microRNA in the lungs of patients with systemic sclerosis interstitial lung disease compared to controls

ECM-receptor interaction (hsa04512)

<1e-16

16

3

let-7e,

miR-4459,

let-7f

Ubiquitin mediated proteolysis (hsa04120)

<1e-16

76

9

miR-182,

miR-141,

miR-125a,

miR-379,

miR-4484,

miR-574,

miR-3613,

miR-4739,

miR-20a

Wnt signaling pathway (hsa04310)

<1e-16

79

10

miR-155,

miR-205,

miR-1224,

let-7e,

miR-4459,

miR-762,

miR-4668,

let-7f,

miR-3613,

miR-20a

MAPK signaling pathway (hsa04010)

<1e-16

132

13

miR-21,

miR-155,

miR-125a,

let-73,

miR-4530,

miR-1207,

miR-149,

miR-762,

let-7f,

miR-199a,

miR-199b,

miR-3613,

miR-20a

Pathways in cancer (hsa05200)

<1e-16

166

15

miR-21,

miR-155,

miR-182,

miR-205,

miR-1224,

let-7e,

miR-4459,

miR-4484,

let-7f,

miR-199a,

miR-574,

miR-199b,

miR-3613,

miR-4739,

miR-20a

Axon guidance (hsa04360)

7.77E-16

72

11

miR-155,

miR-205,

miR-1224,

miR-379,

miR-4741,

miR-762,

miR-4689,

miR-4484,

miR-3613,

miR-4739,

miR-20a

PI3K-Akt signaling pathway (hsa04151)

2.74E-14

137

12

miR-155,

miR-182,

let-7e,

miR-379,

miR-4459,

miR-149,

miR-4668,

let-7f,

miR-199a,

miR-199b,

miR-3613,

miR-20a

TGF-beta signaling pathway (hsa04350)

5.88E-14

41

10

miR-21,

miR-205,

let-7e,

miR-4668,

miR-451a,

miR-4484,

let-7f,

miR-3613,

miR-20a,

miR-455

ErB signaling pathway (hsa04012)

1.17E-13

40

12

miR-155,

miR-205,

miR-193a,

miR-200b,

miR-4530,

miR-451a,

miR-4484,

miR-199a,

miR-199b,

miR-200c,

miR-3613,

miR-20a

Transcriptional misregulation in cancer (hsa05202)

1.23E-13

83

11

miR-182,

miR-205,

miR-1224,

let-7e,

miR-1207,

miR-149,

miR-4668,

let-7f,

miR-3613,

miR-20a,

miR-455