Skip to main content

Advertisement

Table 2 Top 10 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways related to the most expressed microRNA in the lungs of patients with systemic sclerosis interstitial lung disease compared to controls

From: miR-155 in the progression of lung fibrosis in systemic sclerosis

KEGG pathway p value #genes miRNA      
ECM-receptor interaction (hsa04512) <1e-16 16 3 let-7e, miR-4459, let-7f   
Ubiquitin mediated proteolysis (hsa04120) <1e-16 76 9 miR-182, miR-141, miR-125a, miR-379, miR-4484,
     miR-574, miR-3613, miR-4739, miR-20a  
Wnt signaling pathway (hsa04310) <1e-16 79 10 miR-155, miR-205, miR-1224, let-7e, miR-4459,
     miR-762, miR-4668, let-7f, miR-3613, miR-20a
MAPK signaling pathway (hsa04010) <1e-16 132 13 miR-21, miR-155, miR-125a, let-73, miR-4530,
     miR-1207, miR-149, miR-762, let-7f, miR-199a,
     miR-199b, miR-3613, miR-20a   
Pathways in cancer (hsa05200) <1e-16 166 15 miR-21, miR-155, miR-182, miR-205, miR-1224,
     let-7e, miR-4459, miR-4484, let-7f, miR-199a,
     miR-574, miR-199b, miR-3613, miR-4739, miR-20a
Axon guidance (hsa04360) 7.77E-16 72 11 miR-155, miR-205, miR-1224, miR-379, miR-4741,
     miR-762, miR-4689, miR-4484, miR-3613, miR-4739,
     miR-20a     
PI3K-Akt signaling pathway (hsa04151) 2.74E-14 137 12 miR-155, miR-182, let-7e, miR-379, miR-4459,
     miR-149, miR-4668, let-7f, miR-199a, miR-199b,
     miR-3613, miR-20a    
TGF-beta signaling pathway (hsa04350) 5.88E-14 41 10 miR-21, miR-205, let-7e, miR-4668, miR-451a,
     miR-4484, let-7f, miR-3613, miR-20a, miR-455
ErB signaling pathway (hsa04012) 1.17E-13 40 12 miR-155, miR-205, miR-193a, miR-200b, miR-4530,
     miR-451a, miR-4484, miR-199a, miR-199b, miR-200c,
     miR-3613, miR-20a    
Transcriptional misregulation in cancer (hsa05202) 1.23E-13 83 11 miR-182, miR-205, miR-1224, let-7e, miR-1207,
     miR-149, miR-4668, let-7f, miR-3613, miR-20a,
     miR-455     
  1. In sequence: pathway names, significance levels based on p value, number of targeted genes, number of miRNA targeting each pathway, and list of miRNA related to each pathway