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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice

Fig. 1

Establishment of periodontal disease in B10.RIII mice. a Schematic diagram of the experimental design. b (i), (ii) Polybacterial-infected mice IgG, IgM systemic immune response against P. gingivalis (Pg), T. denticola (Td), and T. forsythia (Tf), respectively; (iii), (iv) polybacterial-infected + collagen type II (CII)-immunized mice IgG, IgM systemic immune response against Pg, Td, and Tf, respectively. c (i) Representative images of horizontal alveolar bone resorption area in mandibular surfaces of B10.RIII mice; (ii) total alveolar bone resorption in B10.RIII mice. Each bar indicates the mean alveolar bone resorption for three molars in each quadrant. Three bacteria were used in oral infection for 24 weeks. N = 10 in each group. *P < 0.05, ***P < 0.001. Cont control

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