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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice

Fig. 3

Chronic periodontal infection and concomitant collagen immunization aggravates experimental arthritic pathological change. Histological assessment of ankle joints after immunization with collagen type II (CII). a Synovial joint inflammation, b pannus formation and c skeletal damage scores on H&E-stained tissue sections. Data are mean + SEM (scale 0–3) of six mice per group. d Histopathological evidence of development of arthritis in B1O.RIII mice. H&E staining of ankle joint tissue from B10.RIII mice (top row). H&E staining of paw tissue from B10.RIII mice (bottom row). Yellow arrowheads indicate inflammatory infiltration; thick blue arrows indicate pannus formation and thick black arrows indicates cartilage destruction. Original magnification ×20. N = 6 in each group. Cont control, Pg/Td/Tf, P. gingivalis/T. denticola/T. forsythia

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