Skip to main content

Advertisement

Table 2 Genes to prioritise from protein-protein interaction analyses of SNPs and targets of myositis-specific antibodies (MSA) or myositis-associated autoantibodies (MAA)

From: Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies

All MSA/MAA targets (n = 28) Subset of MSA/MAA targetsa (n = 21) All SNPs (n = 22) All SNPs (n = 22) and subsets of MSA/MAA targetsa (n = 21)
Gene P corr value Gene P corr value Gene P corr value Gene P corr value
UBA2 3.03 × 10-4 GARS 3.16 × 10-4 UBE3B 8.03 × 10-4 TRAF6 3.01 × 10-4
GARS 5.05 × 10-4 PMS1 4.21 × 10-4 TRAF6 2.11 × 10-3 UBE3B 4.01 × 10-4
PMS1 3.63 × 10-3 UBA2 3.47 × 10-3    GARS 1.20 × 10-3
TRIM24 4.74 × 10-3 IARS 5.68 × 10-3    TARS 3.90 × 10-3
YARS 8.37 × 10-3 YARS 1.09 × 10-2    PSMD3 6.99 × 10-3
TRIM28 8.97 × 10-3 HARS 1.15 × 10-2    UBA2 1.19 × 10-2
NARS 9.17 × 10-3 AARS 1.78 × 10-2    PMS1 1.67 × 10-2
TRIM33 1.10 × 10-2 NARS 3.23 × 10-2    HSPA1B 2.73 × 10-2
IARS 1.15 × 10-2      YARS 3.79 × 10-2
MLH1 1.79 × 10-2      IARS 3.98 × 10-2
HARS 1.95 × 10-2      HARS 4.61 × 10-2
CHD3 2.67 × 10-2      HSPA1A 4.94 × 10-2
FARSA 3.02 × 10-2       
AARS 3.10 × 10-2       
TARS 3.23 × 10-2       
EXOSC9 3.43 × 10-2       
FARSB 4.61 × 10-2       
  1. Listed in order of significance from most to least significant. P cor -values corrected for multiple testing. aSubset of autoantibody targets formed by selecting one protein from each complex.