Table 2 Genes to prioritise from protein-protein interaction analyses of SNPs and targets of myositis-specific antibodies (MSA) or myositis-associated autoantibodies (MAA)
All MSA/MAA targets (n = 28) | Subset of MSA/MAA targetsa (n = 21) | All SNPs (n = 22) | All SNPs (n = 22) and subsets of MSA/MAA targetsa (n = 21) | ||||
|---|---|---|---|---|---|---|---|
Gene | P corr value | Gene | P corr value | Gene | P corr value | Gene | P corr value |
UBA2 | 3.03 × 10-4 | GARS | 3.16 × 10-4 | UBE3B | 8.03 × 10-4 | TRAF6 | 3.01 × 10-4 |
GARS | 5.05 × 10-4 | PMS1 | 4.21 × 10-4 | TRAF6 | 2.11 × 10-3 | UBE3B | 4.01 × 10-4 |
PMS1 | 3.63 × 10-3 | UBA2 | 3.47 × 10-3 | GARS | 1.20 × 10-3 | ||
TRIM24 | 4.74 × 10-3 | IARS | 5.68 × 10-3 | TARS | 3.90 × 10-3 | ||
YARS | 8.37 × 10-3 | YARS | 1.09 × 10-2 | PSMD3 | 6.99 × 10-3 | ||
TRIM28 | 8.97 × 10-3 | HARS | 1.15 × 10-2 | UBA2 | 1.19 × 10-2 | ||
NARS | 9.17 × 10-3 | AARS | 1.78 × 10-2 | PMS1 | 1.67 × 10-2 | ||
TRIM33 | 1.10 × 10-2 | NARS | 3.23 × 10-2 | HSPA1B | 2.73 × 10-2 | ||
IARS | 1.15 × 10-2 | YARS | 3.79 × 10-2 | ||||
MLH1 | 1.79 × 10-2 | IARS | 3.98 × 10-2 | ||||
HARS | 1.95 × 10-2 | HARS | 4.61 × 10-2 | ||||
CHD3 | 2.67 × 10-2 | HSPA1A | 4.94 × 10-2 | ||||
FARSA | 3.02 × 10-2 | ||||||
AARS | 3.10 × 10-2 | ||||||
TARS | 3.23 × 10-2 | ||||||
EXOSC9 | 3.43 × 10-2 | ||||||
FARSB | 4.61 × 10-2 | ||||||