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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Enhanced IgG4 production by follicular helper 2 T cells and the involvement of follicular helper 1 T cells in the pathogenesis of IgG4-related disease

Fig. 3

Induction of the differentiation of naïve B cells into plasmablasts by circulating follicular helper T (Tfh) cell subsets. Sorted Tfh subsets (Tfh1, Tfh2, and Tfh17 cells) from patients with IgG4-related disease (IgG4-RD) or healthy controls (HC) were co-cultured with autologous naive B cells for 7 days and analyzed by flow cytometry. Representatives of the CD19+CD27+CD38+ plasmablast population (a). Percentage of plasmablasts at day 7 induced by different Tfh cell subsets from patients with IgG4-RD and HC (b). ***P < 0.0001 for analysis using the Kruskal-Wallis test

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Arthritis Research & Therapy

ISSN: 1478-6362

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