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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation

Fig. 3

PAD4 contributes to inflammatory infiltrates in TNF-α-driven lung inflammation. H&E-stained lung sections from 2-, 3.5-, and 5-month-old TNF+PAD4+/+ and TNF+PAD4-/- littermates were scored for the severity of perivascular infiltrates and interstitial infiltrates. a Representative images of TNF+PAD4+/+ and TNF+PAD4-/- lungs at 3.5 months of age (200×, bar 0.1 mm). Arrows indicate representative perivascular lymphoid infiltrates. Average and SEM for severity of perivascular infiltrates (b) and interstitial infiltrates (c) are shown (2 months old: n = 5 littermate pairs, 3.5 months old: n = 6 TNF+PAD4+/+ and 7 TNF+PAD4-/- mice, 5 months old: n = 10 TNF+PAD4+/+ and 11 TNF+PAD4-/- mice; * p < 0.05). PAD4 peptidylarginine deiminase 4, TNF-α tumor necrosis factor alpha

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