Fig. 3

PAD4 contributes to inflammatory infiltrates in TNF-α-driven lung inflammation. H&E-stained lung sections from 2-, 3.5-, and 5-month-old TNF⁺PAD4^+/+ and TNF⁺PAD4^-/- littermates were scored for the severity of perivascular infiltrates and interstitial infiltrates. a Representative images of TNF⁺PAD4^+/+ and TNF⁺PAD4^-/- lungs at 3.5 months of age (200×, bar 0.1 mm). Arrows indicate representative perivascular lymphoid infiltrates. Average and SEM for severity of perivascular infiltrates (b) and interstitial infiltrates (c) are shown (2 months old: n = 5 littermate pairs, 3.5 months old: n = 6 TNF⁺PAD4^+/+ and 7 TNF⁺PAD4^-/- mice, 5 months old: n = 10 TNF⁺PAD4^+/+ and 11 TNF⁺PAD4^-/- mice; ^* p < 0.05). PAD4 peptidylarginine deiminase 4, TNF-α tumor necrosis factor alpha