Fig. 1

Biomarker need in clinical context. Typical clinical sequence in systemic juvenile idiopathic arthritis (SJIA) from disease onset, diagnosis to clinical resolution and flare. Specific time points where there is a need for diagnostic and prognostic biomarkers are indicated. Diagnostic markers are indicated as follows: D1 SJIA versus other non-JIA conditions, D2 SJIA versus other JIA subtypes. Prognostic markers are indicated as follows: P1 prognostic for flare, P2 prognostic for increased disease activity, P3 prognostic for macrophage activation syndrome (MAS) or differentiating MAS from SJIA flare. Adapted from Hinze et al. 2015 [8]