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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: The unfolded protein response genes in human osteoarthritic chondrocytes: PERK emerges as a potential therapeutic target

Fig. 1

Expression/production of UPR genes in normal and osteoarthritic (OA) human chondrocytes and cartilage. mRNA levels (qPCR, normal [n = 6)] and OA [n = 6]) and protein production (immunohistochemistry [IHC], normal [n = 7] and OA [n = 7]) of (a) ERN1, (b) PERK, (c) ATF6B, and (d) CREB3L2. Illustrated are representative images of cartilage IHC. Data are expressed as mean ± SEM, and p values assessed by the unpaired t test comparing OA to normal chondrocytes. Magnification × 63 (a, b) and × 250 (c and d, upper cartilage zone; e and f, lower zone); boxes indicate where the magnifications were taken, and arrows indicate positively stained chondrocytes

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