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Table 6 Comparisons of allelic frequencies of MEFV mutations of FMF patients with or without accompanying rheumatic diseases

From: Familial Mediterranean fever is no longer a rare disease in Japan

  

FMF

  
  

Rheumatic diseases (+)

Rheumatic diseases (–)

  
  

2n = 52

2n = 332

p

pc

Exon10

M694I

4 (7.7 %) [1/26 (3.8 %)]

48 (14.5 %) [4/166 (2.4 %)]

0.185

2.7738

 

P751L

0

1 (0.3 %)

0.865

12.9687

 

G632S

0

1 (0.3 %)

0.865

12.9687

Exon3

R410H

0

1 (0.3 %)

0.865

12.9687

 

R408Q

8 (15.4 %) [2/26 (7.7 %)]

23 (6.9 %) [0/166 (0 %)]

0.043

0.6419

 

P369S

8 (15.4 %) [2/26 (7.7 %)]

25 (7.5 %) [0/166 (0 %)]

0.060

0.9050

 

R354Q

0

1 (0.3 %)

0.865

12.9687

Exon2

G304R

3 (5.8 %) [0/26 (0 %)]

8 (2.4 %) [1/166 (0.6 %)]

0.176

2.6382

 

E225K

0

1 (0.3 %)

0.865

12.9687

 

R202Q

3 (5.8 %)

14 (4.2 %)

0.411

6.1680

 

E148Q

23 (44.2 %) [4/26 (15.4 %)]

127 (38.3 %) [19/166 (11.4 %)]

0.411

6.1702

 

P115R

0

0

  
 

L110P

8 (15.4 %) [0/26 (0 %)]

37 (11.1 %) [1/166 (0.6 %)]

0.377

5.6513

Exon1

E84K

1 (1.9 %)

11 (3.3 %)

0.500

7.4946

 

R80H

0

0

  
  1. Values are shown as n (%) [% of homozygote]. FMF familial Mediterranean fever, pc corrected p value
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Arthritis Research & Therapy

ISSN: 1478-6362

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