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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Circadian variations in clinical symptoms and concentrations of inflammatory cytokines, melatonin, and cortisol in polymyalgia rheumatica before and during prednisolone treatment: a controlled, observational, clinical experimental study

Fig. 3

Plasma concentrations of cortisol, interleukin (IL)-10, and C-reactive protein (CRP) monitored for 24 h. Ten patients with polymyalgia rheumatica (PMR) and seven non-PMR control subjects were studied before treatment and during the 14th day of treatment with 20 mg of prednisolone. Values are mean ± SEM. Smoothed curves are included. Inverted open triangles, Variation with time in each of the groups (2P < 0.05), except for CRP, in prednisolone-treated patients (not significant). Open squares, Difference between untreated patients and control subjects (2P < 0.05). Filled squares, Effect of prednisolone (2P < 0.05) in both patients and control subjects. Filled circle, Effect of time only in prednisolone-treated groups (interaction) (2P < 0.05)

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