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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Circadian variations in clinical symptoms and concentrations of inflammatory cytokines, melatonin, and cortisol in polymyalgia rheumatica before and during prednisolone treatment: a controlled, observational, clinical experimental study

Fig. 4

Total plasma concentration AUCs for the 24-h observation periods (24-h AUCs). Ten patients with polymyalgia rheumatica (PMR) and seven non-PMR control subjects had melatonin and various cytokines measured before treatment and during the 14th day of treatment with 20 mg of prednisolone. Values are mean ± SEM. Open squares, Difference between untreated patients and control subjects (2P < 0.05). Filled squares, Effect of prednisolone (2P < 0.05). IL interleukin

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