Cases n = 112 | Controls n = 112 | Remainder of the cohorta n = 11,059 | |
---|---|---|---|
Matching criteria | |||
Sex, male | 48 (42.9) | 48 (42.9) | 2536 (22.9)‡ |
Age, years, mean (SD) | 63.7 (9.1) | 63.7 (9.1) | 55.9 (12.5)‡ |
Hypertension | 67 (60.4) | 68 (60.7) | 4102 (37.1)‡ |
Coronary heart disease | 28 (25.2) | 26 (23.2) | 622 (5.6)‡ |
Heart failure | 7 (6.3) | 7 (6.3) | 242 (2.2)‡ |
Previous cerebrovascular event | 0 (0) | 2 (1.8) | 146 (1.3) |
Hyperlipoproteinemia | 19 (17.1) | 18 (16.1) | 869 (7.9)‡ |
Time to MI/index date, month, mean (SD) | 31.0 (24.9) | 29.5 (23.9) | NA |
Unmatched criteria | |||
Observation time, months, mean (SD) | 52.6 (28.6) | 60.2 (28.0)† | 44.4 (32.7)‡ |
Disease duration, years, mean (SD) | 11.4 (10.6) | 11.4 (9.4) | 10.0 (9.1) |
Rheumatoid factor positive | 83 (74.1) | 85 (75.9) | 7942 (72.1) |
CRP, mg/L, mean (SD) | 23.5 (27.0) | 16.5 (22.1)† | 18.4 (26.6)‡ |
ESR, mm/h, mean (SD) | 39.2 (28.9) | 30.7 (20.6)† | 31.3 (23.0)‡ |
DAS28, mean (SD) | 5.6 (1.3) | 5.5 (1.3) | 5.2 (1.3)‡ |
FFbH, mean (SD) | 53.1 (24.8) | 58.4 (23.3) | 63.0 (23.3)‡ |
Smoking, current | 25 (22.3) | 19 (17.0) | 2355 (21.3) |
Smoking, former | 35 (31.3) | 24 (21.4) | 2589 (23.4) |
Smoking, never | 35 (31.3) | 61 (54.5) | 4698 (42.5) |
Smoking, unknown | 17 (15.2) | 8 (7.1) | 1417 (12.8) |
BMI, mean (SD) | 28.1 (5.6) | 26.7 (4.0)† | 26.6 (5.3)‡ |
BMI ≥30 kg/m2 | 34 (30.4) | 19 (17.0)† | 2514 (22.7) |
Diabetes mellitus | 26 (23.4) | 14 (12.5)† | 1075 (9.7)‡ |
Chronic renal disease | 11 (9.9) | 8 (7.1) | 397 (3.6)‡ |
COPD | 12 (10.8) | 13 (11.6) | 495 (4.5)‡ |
No. of previous csDMARDs, mean (SD) | 2.6 (1.4) | 2.8 (1.5) | 2.4 (1.3) |
No. of previous bDMARDs, mean (SD) | 0.5 (1.0) | 0.4 (0.9) | 0.3 (0.7) |
Oral glucocorticoids | 103 (93.6) | 87 (77.7)† | 8788 (79.6)‡ |
Glucocorticoids, <5 mg/day | 12 (10.9) | 29 (25.9) | 2981 (27.0) |
Glucocorticoids, 5–10 mg/day | 64 (58.2) | 46 (41.1) | 4997 (45.3)‡ |
Glucocorticoids, ≥10 mg/day | 34 (30.9) | 37 (33.0) | 3048 (27.6)‡ |
Non-selective NSAIDs | 47 (42.0) | 39 (34.8) | 4260 (38.5) |
COX-2 inhibitors | 17 (15.2) | 23 (20.5) | 1699 (15.4) |
Any NSAIDs | 62 (55.4) | 62 (55.4) | 5895 (53.3) |
No CV treatmentb | 27/75 (36.0) | 13/75 (17.3)† | 967/4584 (21.1)‡ |