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Table 3 Characteristics of cases and matched controls within six months before the MI/index date

From: Impact of disease activity and treatment of comorbidities on the risk of myocardial infarction in rheumatoid arthritis

 

Cases

n = 105

Controls

n = 105

P value

CRP, mg/L, mean (SD)

17.6 (25.0)

10.4 (14.6)

0.011

ESR, mm/h, mean (SD)

36.1 (26.5)

22.6 (16.2)

<0.001

DAS28, mean (SD)

4.3 (1.4)

4.0 (1.5)

0.22

Tender joint count, mean (SD)

4.2 (5.0)

4.4 (5.6)

0.71

Swollen joint count, mean (SD)

3.8 (5.0)

4.6 (5.4)

0.17

NRS patient global health 0–10, mean (SD)

5.1 (2.2)

4.9 (2.0)

0.41

FFbH, mean (SD)

58.7 (27.1)

61.0 (24.2)

0.32

TNFi

50 (47.6 %)

55 (52.4 %)

0.41

Other bDMARDs

21 (20.0 %)

23 (21.9 %)

0.66

csDMARDs only

33 (31.4 %)

23 (21.9 %)

0.11

Glucocorticoids, <5 mg/day

44 (41.9 %)

62 (59.6 %)

 

Glucocorticoids, 5–10 mg/day

45 (42.9 %)

34 (32.7 %)

0.008

Glucocorticoids, ≥10 mg/day

16 (15.2 %)

8 (7.7 %)

 

Non-selective NSAIDs

60 (57.1 %)

62 (59.0 %)

0.77

COX-2 inhibitors

28 (26.7 %)

36 (34.3 %)

0.19

Any NSAID

72 (68.6 %)

78 (74.3 %)

0.33

  1. Case–control pairs with missing C-reactive protein (CRP) values were not included in this analysis. Data represent averages of all reported values within 6 months before the myocardial infarction (MI)/index date. All values are numbers of patients (%) unless otherwise specified. Tumour necrosis factor inhibitors (TNFi), other biologic disease-modifying antirheumatic drugs (bDMARDs) and conventional synthetic DMARDS (csDMARDs) were counted if the patient received at least one dose of the drug within 6 months before the MI/index date. For nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 (COX-2) inhibitors, data represent use in the 24 months before the MI/index date
  2. SD standard deviation, ESR erythrocyte sedimentation rate, DAS28 disease activity score based on 28 joints, NRS numeric rating scale, FFbH Hannover Functional Status Questionnaire