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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in primary human osteoarthritic chondrocytes

Fig. 5

IL-1β-induced production of MMP-3 (a), IL-6 (b), and PGE2 (c) in the cartilage is attenuated by genetic depletion of TRPA1. Cartilage samples were obtained from TRPA1-deficient (knockout, KO) and corresponding wild-type (WT) mice. The samples were cultured with and without IL-1β (100 pg/ml) for 42 h and thereafter the culture medium was collected and analyzed for concentrations of MMP-3, IL-6, and PGE2 by immunoassay. The results are expressed as mean + SEM, n = 6–9. Unpaired t test was used in the statistical analysis; * p < 0.05, ** p < 0.01, and *** p < 0.001 compared to the WT mice. IL interleukin, MMP matrix metalloproteinase, PGE 2 prostaglandin E2, TRPA1 transient receptor potential ankyrin 1

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